Primary sequence of cyclic nucleotide phosphodiesterase isozymes and the design of selective inhibitors.

@article{Beavo1990PrimarySO,
  title={Primary sequence of cyclic nucleotide phosphodiesterase isozymes and the design of selective inhibitors.},
  author={Joseph A. Beavo and David H. Reifsnyder},
  journal={Trends in pharmacological sciences},
  year={1990},
  volume={11 4},
  pages={150-5}
}
Primary sequence information has been reported for more than 15 different mammalian cyclic nucleotide phosphodiesterases. Moreover, recent observations suggest that many of these isozymes are selectively expressed in a limited number of cell types. The fact that nearly all these different phosphodiesterases have unique primary sequences in their catalytic or regulatory domains and that they are often selectively expressed implies that it may be possible to modulate individual isozymes using… CONTINUE READING
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