Primary sequence and immunological characterization of beta-subunit of high conductance Ca(2+)-activated K+ channel from smooth muscle.

@article{Knaus1994PrimarySA,
  title={Primary sequence and immunological characterization of beta-subunit of high conductance Ca(2+)-activated K+ channel from smooth muscle.},
  author={H G Knaus and Kimberly Folander and Marga Garcia-Calvo and M. L. Garcia and Gregory J. Kaczorowski and Michael Smith and Richard J Swanson},
  journal={The Journal of biological chemistry},
  year={1994},
  volume={269 25},
  pages={17274-8}
}
The charybdotoxin receptor, purified from bovine tracheal smooth muscle, consists of two subunits (alpha and beta) and, when reconstituted into planar lipid bilayers, forms functional high conductance Ca(2+)-activated K+ channels. Amino acid sequence, obtained from proteolytic fragments of the beta-subunit, was used to design oligonucleotide probes with which cDNAs encoding this protein were isolated. The cDNAs encode a protein of 191 amino acids that contains two hydrophobic (putative… CONTINUE READING
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