Primary sensory neurons regulate Toll-like receptor-4-dependent activity of glial cells in dorsal root ganglia.

@article{Tse2014PrimarySN,
  title={Primary sensory neurons regulate Toll-like receptor-4-dependent activity of glial cells in dorsal root ganglia.},
  author={K-H Tse and Kevin Chow and Wai Keung Leung and Y H Wong and Helen Wise},
  journal={Neuroscience},
  year={2014},
  volume={279},
  pages={10-22}
}
Toll-like receptor-4 (TLR4) has been identified in primary sensory neurons, both in vivo and in vitro, but is reportedly absent from satellite glial cells (SGCs). Herein we reveal that, in rat dorsal root ganglia (DRG), SGCs do express TLR4 but this expression is inhibited by direct contact with neurons. Thus, TLR4 mRNA and protein is strongly up-regulated in isolated DRG glial cells in the absence of neurons. Lipopolysaccharide (LPS) increased cyclooxygenase-2 (COX-2) and tumor necrosis factor… CONTINUE READING

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