Primary sensory neurons: a common final pathway for inflammation in experimental pancreatitis in rats.

@article{Nathan2002PrimarySN,
  title={Primary sensory neurons: a common final pathway for inflammation in experimental pancreatitis in rats.},
  author={Jaimie D Nathan and Ruth Y Peng and Yu Wang and Douglas C McVey and Steven R Vigna and Rodger A. Liddle},
  journal={American journal of physiology. Gastrointestinal and liver physiology},
  year={2002},
  volume={283 4},
  pages={G938-46}
}
We hypothesized that neurogenic inflammation is a common final pathway for parenchymal inflammation in pancreatitis and evaluated the role of primary sensory neurons in secretagogue-induced and obstructive pancreatitis. Neonatal rats received either the primary sensory neuron-denervating agent capsaicin (50 mg/kg s.c.) or vehicle. At 8 wk of age, pancreatitis was produced by six hourly injections of caerulein (50 microg/kg i.p.) or by common pancreaticobiliary duct ligation (CPBDL). The… CONTINUE READING

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Dorsal root ganglion neurons and dorsal roots: effect of neonatal capsaicin

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