Primary sclerosing cholangitis associated with elevated immunoglobulin G4: clinical characteristics and response to therapy.

@article{Bjrnsson2011PrimarySC,
  title={Primary sclerosing cholangitis associated with elevated immunoglobulin G4: clinical characteristics and response to therapy.},
  author={Einar Stef{\'a}n Bj{\"o}rnsson and Suresh T. Chari and Marina Silveira and Andrea A. Gossard and Naoki Takahashi and Thomas C. Smyrk and Keith M Lindor},
  journal={American journal of therapeutics},
  year={2011},
  volume={18 3},
  pages={198-205}
}
Steroid responsive biliary strictures in patients fulfilling criteria for primary sclerosing cholangitis (PSC) have been reported. The clinical course and response to therapy in patients with PSC with elevated immunoglobulin G4 (IgG4) levels has not been investigated previously. Patients with PSC were screened for IgG4-related biliary disease during 2006 to 2008 and data were collected prospectively. A total of 33 out of 285 (12%) patients with PSC (18 males) had elevated IgG4 (>140mg/dL) with… CONTINUE READING
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