Primary sclerosing cholangitis: an update
Therapies are still lacking to cure the disease or to halt its progression, and unfortunately, primary sclerosing cholangitis can recur after transplantation.
Management of primary sclerosing cholangitis and its complications: an algorithmic approach
- MedicineHepatology International
PSC pathogenesis is summarized and an algorithmic approach to diagnostic procedures and recommendations for the management of PSC and its complications are provided, including promising treatment options subject to current clinical trials.
Autoimmune Liver Diseases: Primary Sclerosing Cholangitis
- Medicine, Biology
Primary sclerosing cholangitis is a chronic condition characterized by inflammation, fibrosis, and obliteration involving the intra as well as extrahepatic bile ducts that is frequently associated with other immune-mediated conditions, most notably inflammatory bowel disease.
Primary sclerosing cholangitis: a clinical update.
- MedicineBritish medical bulletin
Novel agents are being developed and trialled in the treatment of PSC, and recent genetic studies have revealed new risk loci, pointing to the importance of the immune system and its interaction with the biome.
Pediatric Primary Sclerosing Cholangitis
There is no known therapy to prevent progression of primary sclerosing cholangitis; however further research on the effectiveness of ursodeoxycholic acid and oral vancomycin therapies is warranted.
Pathogenesis and clinical spectrum of primary sclerosing cholangitis
- MedicineWorld journal of gastroenterology
Despite past and present research, PSC remains an enigmatic biliary disease with few viable treatment options, and liver transplantation is the only known cure for PSC.
Primary Sclerosing Cholangitis
- MedicineThe New England journal of medicine
Among the different cancers complicating PSC, CCA is the most relevant, because it is more frequent and because the prognosis is poor (5-year survival <10%).
Cholestatic Liver Injury: Care of Patients With Primary Biliary Cholangitis or Primary Sclerosing Cholangitis.
- MedicineAACN advanced critical care
Patients with PSC should be monitored for evidence of cholangiocarcinoma, colon cancer, and gallbladder polyps as they are at an increased risk of malignant neoplasms.
SHOWING 1-10 OF 475 REFERENCES
Current concepts in primary sclerosing cholangitis.
- MedicineMayo Clinic proceedings
Until the etiopathogenesis of PSC is further defined, effective therapy is unlikely to be found, and liver transplantation will continue to be an important therapeutic intervention for the management of patients with end-stage PSC.
Primary sclerosing cholangitis: Diagnosis and management
- MedicineCurrent gastroenterology reports
Primary sclerosing cholangitis is a chronic cholestatic liver disease caused by progressive inflammatory destruction of intra hepatic and extrahepatic bile ducts, and ultimately cirrhosis, and affects primarily young to middle-aged men.
Dissecting the genetic susceptibility for cholangiocarcinoma in primary sclerosing cholangitis
- Medicine, BiologyHepatology
Primary sclerosing cholangitis (PSC) is an idiopathic cholestatic liver disease caused by fibrosing inflammation of the bile ducts and represents an established risk factor for development of…
[Primary sclerosing cholangitis].
- MedicineDer Internist
During treatment with UDCA stenoses of major ducts may develop and early endoscopic dilatation is highly effective and in patients with endstage disease, UDCA is not effective and liver transplantation is indicated.
Ischemic-Like Cholangiopathy With Secondary Sclerosing Cholangitis in Critically Ill Patients
- MedicineThe American Journal of Gastroenterology
Ischemic injury of the biliary tree with the formation of biliary casts and subsequent ongoing biliary infection due to multiresistant bacteria seem to be major pathogenic mechanisms in the development of this new entity of sclerosing cholangitis.
Primary sclerosing cholangitis and celiac disease. A novel association.
- MedicineAnnals of internal medicine
The association of primary sclerosing cholangitis and celiac disease was observed in three patients, an association not previously reported, and the relationship between the two diseases remains unknown, although an immunologic connection is suspected.
Advances in the diagnosis of cholangiocarcinoma in patients with primary sclerosing cholangitis
- MedicineLiver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society
Primary sclerosing cholangitis (PSC) is an idiopathic chronic cholestatic liver disease characterized by inflammatory destruction of the biliary tree. It slowly progresses, resulting in biliary…
Primary sclerosing cholangitis: Summary of a workshop
Significant opportunities remain for basic and clinical research into the cause, natural history, and therapy of PSC, which has several atypical features and a strong genetic component.
Patients with asymptomatic primary sclerosing cholangitis frequently have progressive disease.
Sclerosing cholangitis: A focus on secondary causes
A comprehensive review of SSC is offered, including a wide variety of other associations have been reported recently, including autoimmune pancreatitis, portal biliopathy, eosinophillic and/or mast cell cholangitis, hepatic inflammatory pseudotumor, recurrent pyogenic cholangsitis, primary immune deficiency, and AIDS‐related cholANGiopathy.