Primary sclerosing cholangitis

@article{Hirschfield2013PrimarySC,
  title={Primary sclerosing cholangitis},
  author={Gideon M. Hirschfield and Tom Hemming Karlsen and Keith D. Lindor and David H. Adams},
  journal={The Lancet},
  year={2013},
  volume={382},
  pages={1587-1599}
}
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Advances in primary sclerosing cholangitis.
Primary sclerosing cholangitis
Primary sclerosing cholangitis: an update
TLDR
Therapies are still lacking to cure the disease or to halt its progression, and unfortunately, primary sclerosing cholangitis can recur after transplantation.
Management of primary sclerosing cholangitis and its complications: an algorithmic approach
TLDR
PSC pathogenesis is summarized and an algorithmic approach to diagnostic procedures and recommendations for the management of PSC and its complications are provided, including promising treatment options subject to current clinical trials.
Autoimmune Liver Diseases: Primary Sclerosing Cholangitis
TLDR
Primary sclerosing cholangitis is a chronic condition characterized by inflammation, fibrosis, and obliteration involving the intra as well as extrahepatic bile ducts that is frequently associated with other immune-mediated conditions, most notably inflammatory bowel disease.
Primary sclerosing cholangitis: a clinical update.
TLDR
Novel agents are being developed and trialled in the treatment of PSC, and recent genetic studies have revealed new risk loci, pointing to the importance of the immune system and its interaction with the biome.
Pediatric Primary Sclerosing Cholangitis
TLDR
There is no known therapy to prevent progression of primary sclerosing cholangitis; however further research on the effectiveness of ursodeoxycholic acid and oral vancomycin therapies is warranted.
Pathogenesis and clinical spectrum of primary sclerosing cholangitis
TLDR
Despite past and present research, PSC remains an enigmatic biliary disease with few viable treatment options, and liver transplantation is the only known cure for PSC.
Primary Sclerosing Cholangitis
TLDR
Among the different cancers complicating PSC, CCA is the most relevant, because it is more frequent and because the prognosis is poor (5-year survival <10%).
Cholestatic Liver Injury: Care of Patients With Primary Biliary Cholangitis or Primary Sclerosing Cholangitis.
TLDR
Patients with PSC should be monitored for evidence of cholangiocarcinoma, colon cancer, and gallbladder polyps as they are at an increased risk of malignant neoplasms.
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References

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TLDR
Until the etiopathogenesis of PSC is further defined, effective therapy is unlikely to be found, and liver transplantation will continue to be an important therapeutic intervention for the management of patients with end-stage PSC.
Primary sclerosing cholangitis: Diagnosis and management
TLDR
Primary sclerosing cholangitis is a chronic cholestatic liver disease caused by progressive inflammatory destruction of intra hepatic and extrahepatic bile ducts, and ultimately cirrhosis, and affects primarily young to middle-aged men.
Dissecting the genetic susceptibility for cholangiocarcinoma in primary sclerosing cholangitis
Primary sclerosing cholangitis (PSC) is an idiopathic cholestatic liver disease caused by fibrosing inflammation of the bile ducts and represents an established risk factor for development of…
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During treatment with UDCA stenoses of major ducts may develop and early endoscopic dilatation is highly effective and in patients with endstage disease, UDCA is not effective and liver transplantation is indicated.
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Primary sclerosing cholangitis (PSC) is an idiopathic chronic cholestatic liver disease characterized by inflammatory destruction of the biliary tree. It slowly progresses, resulting in biliary…
Primary sclerosing cholangitis: Summary of a workshop
TLDR
Significant opportunities remain for basic and clinical research into the cause, natural history, and therapy of PSC, which has several atypical features and a strong genetic component.
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Sclerosing cholangitis: A focus on secondary causes
TLDR
A comprehensive review of SSC is offered, including a wide variety of other associations have been reported recently, including autoimmune pancreatitis, portal biliopathy, eosinophillic and/or mast cell cholangitis, hepatic inflammatory pseudotumor, recurrent pyogenic cholangsitis, primary immune deficiency, and AIDS‐related cholANGiopathy.
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