Primary sclerosing cholangitis: Diagnosis and management

@article{Charatcharoenwitthaya2006PrimarySC,
  title={Primary sclerosing cholangitis: Diagnosis and management},
  author={Phunchai Charatcharoenwitthaya and Keith D. Lindor},
  journal={Current Gastroenterology Reports},
  year={2006},
  volume={8},
  pages={75-82}
}
Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease caused by progressive inflammatory destruction of intrahepatic and extrahepatic bile ducts, and ultimately cirrhosis. PSC occurs primarily in patients with underlying ulcerative colitis and affects primarily young to middle-aged men. PSC is believed to be an autoimmune disease mediated by immune dysregulation in patients with genetic susceptibility. One possible mechanism for the development of PSC is the homing of… 
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53 Citations
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Methods Citations
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53 Citations

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Leukocytapheresis Therapy Improved Cholestasis in a Patient Suffering from Primary Sclerosing Cholangitis with Ulcerative Colitis
TLDR
Improvement of UC, but also decreased serum alkaline phosphatase, γ-guanosine triphosphate and total bile acids, suggesting improvement of PSC-associated cholestaisis, were seen after treatment with LCAP.
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Primary sclerosing cholangitis (PSC) is a chronic and progressive disease of the biliary tree characterised by concentric, obliterative fibrosis leading to bile duct stricturing and eventually…
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TLDR
The present study aimed to review the current treatment options for patients with primary sclerosing cholangitis and suggest several treatment modalities mainly focusing on the inflammation aspect of this disorder.
Autoimmune cholangitis and cholangiocarcinoma
TLDR
Correct diagnosis of IAC will avoid unnecessary surgery because IAC responds well to steroid therapy and increased IgG4 levels, other organ involvement and response to steroids are keys to distinguishing IAC from CCA.
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Biliary Stent Therapy for Dominant Strictures in Patients Affected by Primary Sclerosing Cholangitis
TLDR
The aim of this article is to review the diagnostic and therapeutic strategies for patients affected by PSC and DS with specific emphasis on the outcomes of patients treated with temporary stents.
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References

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TLDR
Aside from viral hepatitis and alcoholic liver disease, primary sclerosing cholangitis is one of the most common indications for liver transplantation and research aimed toward better understanding the pathogenetic mechanisms and clinical trials with promising new agents are ongoing.
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TLDR
Etanercept, at the dosage used, was well tolerated but not effective in the treatment of PSC, although it may be helpful in treating pruritus due to cholestasis.
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TLDR
Ursodiol (ursodeoxycholic acid) benefits patients with primary biliary cirrhosis, another cholestatic liver disease, and well-documented primary sclerosing cholangitis in a randomized, double-blind study comparing ursodiol with placebo.
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TLDR
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TLDR
In patients with IBD, detection of enlarged perihepatic lymph nodes in US predicted PSC more accurately than conventional serum parameters alone and the sensitivity ratio increased by a factor of 1.13 in favor of the US examination.
Risk factors for recurrence of primary sclerosing cholangitis of liver allograft
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TLDR
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TLDR
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TLDR
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