Primary role of the HLA class II DRB1*0301 allele in Graves disease.

  title={Primary role of the HLA class II DRB1*0301 allele in Graves disease.},
  author={Mohammed Zamani and Marijke Spaepen and Marie Bex and R Bouillon and J. J. Cassiman},
  journal={American journal of medical genetics},
  volume={95 5},
The association of the Graves disease (GD) with HLA DR3 and DQA1*0501 in Caucasians has been described previously. From these studies it could not be determined whether one specific locus was primarily involved. Using a case-control study design, we have examined the role of HLA class II gene polymorphisms in the predisposition for GD in a group of Belgian subjects. We demonstrated that both DRB1*0301 and DQA1*0501 alleles conferred significant susceptibility in the DRB1*0301-DQA1*0501… CONTINUE READING

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