Primary resistance, multidrug resistance, and cross-resistance pathways in HBV as a consequence of treatment failure.

@article{Locarnini2008PrimaryRM,
  title={Primary resistance, multidrug resistance, and cross-resistance pathways in HBV as a consequence of treatment failure.},
  author={Stephen A. Locarnini},
  journal={Hepatology international},
  year={2008},
  volume={2 2},
  pages={147-51}
}
Antiviral resistance is now the single most important factor in treatment failure using nucleos(t)ide analogues (NA). Primary drug resistance mutations refer to amino acid change(s) that result in reduced susceptibility to an antiviral agent. Secondary compensatory mutations restore replication defects associated with primary drug resistance and may be… CONTINUE READING