Primary rat astroglial cultures can generate leukotriene B4.

  title={Primary rat astroglial cultures can generate leukotriene B4.},
  author={Hans-Peter Hartung and Kurt Heininger and Klaus Victor Toyka},
  journal={Journal of neuroimmunology},
  volume={19 3},
Astrocytes are important elements of cellular immune responses in the central nervous system. Eicosanoids exhibit immunomodulatory properties. We studied whether astroglial cells have the capacity to convert arachidonic acid via the lipoxygenase pathway to leukotriene B4 (LTB4). Calcium ionophore A23187 evoked a dose-related release of LTB4 into supernatants of primary culture rat astrocytes. This stimulatory effect was abrogated by the addition of the lipoxygenase inhibitors BW755c and… CONTINUE READING