Primary pulmonary hypertension in a patient with a familial platelet storage pool disease: role of serotonin.

@article{Herv1990PrimaryPH,
  title={Primary pulmonary hypertension in a patient with a familial platelet storage pool disease: role of serotonin.},
  author={Philippe Herv{\'e} and Ludovic Drouet and Christine Dosquet and Jean Marie Launay and Bernadette Rain and G{\'e}rald Simonneau and Jacques Philippe Caen and Pierre Duroux},
  journal={The American journal of medicine},
  year={1990},
  volume={89 1},
  pages={
          117-20
        }
}
Textbook of Pulmonary Vascular Disease
The Human Pulmonary Circulation: Historical Introduction.- Microcirculation of the Lung: Functional and Anatomic Aspects.- Pulmonary Vascular Development.- Pulmonary Vascular Function.- PulmonaryExpand
JPET # 98269 1 Evidence for a control of plasma serotonin levels by 5-HT 2 B receptors in mice
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References

SHOWING 1-10 OF 17 REFERENCES
Stimulation of aortic smooth muscle cell mitogenesis by serotonin.
TLDR
The data indicate that serotonin has a significant mitogenic effect on smooth muscle cells in vitro, which appears to be mediated by specific plasma membrane receptors. Expand
Type beta transforming growth factor in human platelets: release during platelet degranulation and action on vascular smooth muscle cells
TLDR
The data suggest that platelet-mediated proliferation of aortic smooth muscle cells in vivo may not result solely from the stimulatory effect of Platelet-derived growth factor (PDGF), but rather from an interaction of platelet factors which has the intrinsic ability to limit as well as stimulate mitosis. Expand
Magnitude and implications of spontaneous hemodynamic variability in primary pulmonary hypertension.
TLDR
Spontaneous variability in pulmonary pressures and resistances occurred in each patient, with the amount of variation (coefficient of variation) in PA pressure averaging 8% and in total pulmonary resistance 13% over the 6 hours, which correlated with the severity of the disease. Expand
Aggregating platelets contract isolated canine pulmonary arteries by releasing 5-hydroxytryptamine.
TLDR
Five experiments demonstrate that in the canine pulmonary artery 5-hydroxytryptamine is the predominant mediator of the contractile response triggered by platelet aggregation; and unlike in other blood vessels, the endothelium cannot curtail the contractiles response to aggregating platelets. Expand
Molecular defects in interactions of platelets with the vessel wall.
The objectives of this review have been to summarize the recent research on inherited defects involving abnormal platelet function and to illustrate how studies of hemorrhagic syndromes have led toExpand
TERATOMA OF THE TESTIS
Vascular effects of ketanserin (R 41 468), a novel antagonist of 5-HT2 serotonergic receptors.
TLDR
R 41 468 is a potent antagonist of the vasoconstrictor effects of 5-hydroxytryptamine, in particular of its amplifying effect on threshold amounts of norepinephrine, which may help explain its antihypertensive properties. Expand
Determination of acid hydrolases in human platelets.
TLDR
The sensitivity and accuracy of the fluorophor-based assays with 4-methylumbelliferone-containing substrates were markedly better than the chromophore-basedAssays, and the determination of β-glycerophosphatase was particularly inaccurate due to formation of large amounts of phosphate from endogenous sources in the lysates. Expand
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