Primary pulmonary hypertension: a vascular biology and translational research "Work in progress".

@article{Archer2000PrimaryPH,
  title={Primary pulmonary hypertension: a vascular biology and translational research "Work in progress".},
  author={Stephen L Archer and Stuart Rich},
  journal={Circulation},
  year={2000},
  volume={102 22},
  pages={2781-91}
}
Primary pulmonary hypertension (PPH) is a syndrome of dyspnea, chest pain, and syncope defined by increased pulmonary vascular resistance and the absence of a known cause. It also occurs in a familial form, which is linked to unidentified genes on chromosome 2. This syndrome is characterized by abnormalities of pulmonary vascular biology in each compartment of the blood vessel. The lumen has a prothrombotic diathesis, the endothelium displays an excessive production of vasoconstrictors relative… CONTINUE READING
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