Primary prophylaxis and early secondary prophylaxis in children

@inproceedings{Coppola2017PrimaryPA,
  title={Primary prophylaxis and early secondary prophylaxis in children},
  author={Antonio Coppola and Massimo Franchini and Annarita Tagliaferri},
  year={2017}
}
A four-decade clinical experience and recent evidence from randomised controlled studies definitively recognised primary prophylaxis, i.e. the regular infusion of factor concentrates started after the first haemarthrosis and/or before the age of two years, as the first-choice treatment in children with severe haemophilia. The available data clearly show that preventing bleeding since an early age enables to avoid or reduce the clinical impact of muscle-skeletal impairment from haemophilic… CONTINUE READING

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