Primary-progressive multiple sclerosis
@article{Miller2007PrimaryprogressiveMS, title={Primary-progressive multiple sclerosis}, author={D. Miller and S. Leary}, journal={The Lancet Neurology}, year={2007}, volume={6}, pages={903-912} }
About 10-15% of patients with multiple sclerosis (MS) present with gradually increasing neurological disability, a disorder known as primary-progressive multiple sclerosis (PPMS). Compared with relapse-onset multiple sclerosis, people with PPMS are older at onset and a higher proportion are men. Inflammatory white-matter lesions are less evident but diffuse axonal loss and microglial activation are seen in healthy-looking white matter, in addition to cortical demyelination, and quantitative MRI… CONTINUE READING
Paper Mentions
295 Citations
The role of advanced magnetic resonance imaging techniques in primary progressive MS
- Psychology, Medicine
- Journal of Neurology
- 2011
- 22
- Highly Influenced
Diagnostic modalities in multiple sclerosis: Perspectives in children
- Medicine
- Biomedical journal
- 2014
- 9
- PDF
Meningeal inflammation plays a role in the pathology of primary progressive multiple sclerosis.
- Medicine
- Brain : a journal of neurology
- 2012
- 241
- PDF
CSF inflammation and axonal damage are increased and correlate in progressive multiple sclerosis
- Medicine
- Multiple sclerosis
- 2013
- 67
Secondary Progressive Multiple Sclerosis: Definition and Measurement
- Medicine
- CNS Drugs
- 2016
- 23
- Highly Influenced
- PDF
References
SHOWING 1-10 OF 198 REFERENCES
Cord atrophy separates early primary progressive and relapsing remitting multiple sclerosis
- Medicine
- Journal of Neurology, Neurosurgery & Psychiatry
- 2006
- 69
Imaging primary progressive multiple sclerosis: the contribution of structural, metabolic, and functional MRI techniques
- Medicine
- Multiple sclerosis
- 2004
- 33
Primary progressive multiple sclerosis: a 5-year clinical and MR study.
- Medicine
- Brain : a journal of neurology
- 2003
- 118
- PDF
The normal appearing grey matter in primary progressive multiple sclerosis
- Medicine
- Journal of Neurology
- 2003
- 115
Cortical demyelination and diffuse white matter injury in multiple sclerosis.
- Medicine
- Brain : a journal of neurology
- 2005
- 1,437
- PDF
The pathogenesis of primary progressive multiple sclerosis: antibody-mediated attack and no repair?
- Medicine
- Journal of Clinical Neuroscience
- 2004
- 38
- PDF
A comparison of the pathology of primary and secondary progressive multiple sclerosis.
- Medicine
- Brain : a journal of neurology
- 1994
- 286
Axonal damage in acute multiple sclerosis lesions.
- Medicine
- Brain : a journal of neurology
- 1997
- 1,474
- PDF
Multiple sclerosis: current and future treatment options.
- Medicine
- Endocrine, metabolic & immune disorders drug targets
- 2007
- 26