Primary-progressive multiple sclerosis

  title={Primary-progressive multiple sclerosis},
  author={D. Miller and S. Leary},
  journal={The Lancet Neurology},
  • D. Miller, S. Leary
  • Published 2007
  • Medicine
  • The Lancet Neurology
  • About 10-15% of patients with multiple sclerosis (MS) present with gradually increasing neurological disability, a disorder known as primary-progressive multiple sclerosis (PPMS). Compared with relapse-onset multiple sclerosis, people with PPMS are older at onset and a higher proportion are men. Inflammatory white-matter lesions are less evident but diffuse axonal loss and microglial activation are seen in healthy-looking white matter, in addition to cortical demyelination, and quantitative MRI… CONTINUE READING
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