Primary progressive multiple sclerosis: part of the MS disease spectrum or separate disease entity?


Multiple sclerosis (MS), the most frequent demyelinating disease, is characterized by a variable disease course. The majority of patients starts with relapsing remitting (RR) disease; approximately 50–60% of these patients progress to secondary progressive (SP) disease. Only about 15% of the patients develop a progressive disease course from onset, termed… (More)
DOI: 10.1007/s00401-012-0953-0


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