Primary prevention of cardiovascular disease with atorvastatin in type 2 diabetes in the Collaborative Atorvastatin Diabetes Study (CARDS): multicentre randomised placebo-controlled trial

@article{Colhoun2004PrimaryPO,
  title={Primary prevention of cardiovascular disease with atorvastatin in type 2 diabetes in the Collaborative Atorvastatin Diabetes Study (CARDS): multicentre randomised placebo-controlled trial},
  author={H. Colhoun and D. Betteridge and P. Durrington and G. Hitman and on behalf of the Cards investigators},
  journal={The Lancet},
  year={2004},
  volume={364},
  pages={685-696}
}
  • H. Colhoun, D. Betteridge, +2 authors on behalf of the Cards investigators
  • Published 2004
  • Medicine
  • The Lancet
  • BACKGROUND Type 2 diabetes is associated with a substantially increased risk of cardiovascular disease, but the role of lipid-lowering therapy with statins for the primary prevention of cardiovascular disease in diabetes is inadequately defined. [...] Key MethodMETHODS 2838 patients aged 40-75 years in 132 centres in the UK and Ireland were randomised to placebo (n=1410) or atorvastatin 10 mg daily (n=1428).Expand Abstract
    3,353 Citations

    Paper Mentions

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    References

    SHOWING 1-10 OF 36 REFERENCES
    Dyslipidemia management in adults with diabetes.
    • 230
    • PDF