Primary portal venopathy in the golden hamster treated with low doses of dimethylnitrosamine.

@article{Ungar1984PrimaryPV,
  title={Primary portal venopathy in the golden hamster treated with low doses of dimethylnitrosamine.},
  author={H G Ungar},
  journal={Liver},
  year={1984},
  volume={4 4},
  pages={244-54}
}
Ingestion of dimethylnitrosamine in a low dose and for a limited period by hamsters resulted in primary intrahepatic pylephlebitis. The process began at 24 h and progressed within 2-4 weeks to narrowing and, eventually, to partial obstruction of the portal bed. The lesions were characterized by endothelial necrosis followed by infiltrations of lymphoid cells extending into the portal tracts. Superficial lesions of terminal hepatic veins and parenchymal changes occurred only after a lapse of… CONTINUE READING