Primary porcine brain microvascular endothelial cells: biochemical and functional characterisation as a model for drug transport and targeting.

@article{Smith2007PrimaryPB,
  title={Primary porcine brain microvascular endothelial cells: biochemical and functional characterisation as a model for drug transport and targeting.},
  author={Mathew Wayne Smith and Yadollah Omidi and Mark Gumbleton},
  journal={Journal of drug targeting},
  year={2007},
  volume={15 4},
  pages={253-68}
}
The blood-brain barrier (BBB) remains a significant obstacle to the delivery of therapeutic agents into the central nervous system (CNS). Primary cell cultures of brain capillary endothelial cells represent the closest possible phenotype to the in vivo BBB cell providing a convenient model for the study of transport systems and events that mediate solute delivery to the CNS. In this investigation we have characterized an in vitro primary BBB model from porcine brain microvascular endothelial… CONTINUE READING