Primary pigmented nodular adrenocortical disease (PPNAD): immunohistochemical and in situ hybridization analysis of steroidogenic enzymes in eight cases.

@article{Sasano1992PrimaryPN,
  title={Primary pigmented nodular adrenocortical disease (PPNAD): immunohistochemical and in situ hybridization analysis of steroidogenic enzymes in eight cases.},
  author={Hisanobu Sasano and Soichiro Miyazaki and Takashi Sawai and Nobuaki Sasano and Hiroshi Nagura and Hiroomi Funahashi and Motohiko Aiba and Hiroshi Demura},
  journal={Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc},
  year={1992},
  volume={5 1},
  pages={23-9}
}
Primary pigmented nodular adrenocortical disease (PPNAD) is a rare but an interesting adrenocortical disorder associated with ACTH-independent hypercortisolism. We have studied eight cases of the adrenals with PPNAD by immunohistochemistry of all steroidogenic enzymes involved in cortisol biosynthesis (P-45scc, 3 beta-HSD, P-450c21, P-45017 alpha, and P-45011 beta) and also by performing in situ hybridization of P-45017 alpha in seven cases in order to localize the sites of specific… CONTINUE READING

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