Primary peritoneal carcinoma in a UK cancer center: comparison with advanced ovarian carcinoma over a 5‐year period

  title={Primary peritoneal carcinoma in a UK cancer center: comparison with advanced ovarian carcinoma over a 5‐year period},
  author={Kenneth Jaaback and Linmarie Ludeman and N L Clayton and Lynn Hirschowitz},
  journal={International Journal of Gynecological Cancer},
The relative incidence of primary peritoneal carcinoma (PPCa) and advanced (FIGO stage III or IV) ovarian serous carcinoma (AOSCa) was assessed over 5 years at a UK cancer center, and the sociodemographic, clinical, and survival data were compared. There were 23 women with PPCa and 55 with AOSCa. The ratio of PPCa:AOSCa was higher than previously reported. No statistical difference was found between the two groups with regard to age (mean 64.43 vs 64.07 years, P= 0.9), parity (1.6 vs 1.8, P= 1… 

Figures and Tables from this paper

Primary Peritoneal Serous Papillary Carcinoma: A Clinical and Pathological Study
Gynecologist should be aware of PPSPC when abdominal distension, gross ascites and a raised level of CA125 in women without ovarian enlargement, and Cytoreductive surgery combined with pre/postoperative platinum-based chemotherapy may be effective for PPS PC patients.
Extraovarian primary peritoneal carcinoma
In 1959, Swerdlow reported a case of a 27-year-old woman with a pelvic tumour that seemed to arise from the peritoneum, in the presence of normal ovaries, fallopian tubes and uterus, and that was
Primary Peritoneal Carcinoma: A Case Report of Primary Peritoneal Papilary Serous Adenocarcinoma in a 59 Year Old Postmenopausal Woman
Management of primary peritoneal carcinoma should involve surgical debulking and appropriate chemotherapy as in ovarian carcinoma, though rare, if the peritoneum is involved in a malignancy of an unknown primary source.
Primary peritoneal carcinoma: an uncommon entity
The ovary and the peritoneal epithelium share a common embryological origin and the diagnosis of PPCa is based on minimal or non-involvement of the ovaries, and is thought to account for 10% of ovarian malignancies.
Should All Cases of High-Grade Serous Ovarian, Tubal, and Primary Peritoneal Carcinomas Be Reclassified as Tubo-Ovarian Serous Carcinoma?
High-grade serous carcinomas, whether classified as ovarian/tubal/peritoneal, seem to behave as one disease entity with no significant difference in survival outcomes, therefore supporting the proposition of a separate classification of “tubo-ovarianSerous carcinoma”.
Serous tubal intraepithelial carcinoma: its potential role in primary peritoneal serous carcinoma and serous cancer prevention.
  • J. Carlson, A. Miron, C. Crum
  • Medicine
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • 2008
The fimbria is the source of nearly one half of PPSCs, suggesting serous malignancy originates in the tubal mucosa but grows preferentially at a remote peritoneal site.
The involvement of retroperitoneal lymph nodes in primary serous-papillary peritoneal carcinoma. a systematic review of the literature.
Metastasis of primary serous-papillary peritoneal carcinoma to retroperitoneal lymph nodes is not an infrequent occurrence, but there is no evidence of a distinct pattern of spread.


Papillary serous carcinoma of the peritoneal surface: matched-case comparison with papillary serous ovarian carcinoma.
Patients with PSPS have more limited cytoreduction, shorter disease-free interval, and shorter overall survival time, and such differences prompt re-evaluation of treatment modalities for PSPS and recognition that this is a condition distinct from PSOC.
Primary peritoneal serous papillary carcinoma: A new epidemiologic trend? A matched-case comparison with ovarian serous papillary cancer
PPSPC and OSPC might be two distinct cancers, presenting a new epidemiologic trend regarding the increased incidence, and three-year survival analysis demonstrated a significantly worse survival rate for the PPSPC group than for the O SPC group.
Extraovarian peritoneal serous papillary carcinoma. A clinicopathologic study of 31 cases
The rate and clinical features of patients admitted to King George V Hospital with extraovarian peritoneal serous papillary carcinoma during a 9‐year period were reviewed and there was no difference in actuarial survival.
Normal-Sized Ovary Carcinoma Syndrome
A clinical situation occasionally presents in which diffuse metastatic disease of the peritoneal cavity is noted, but the ovaries are of normal size, with or without a fine granularity on their
Serous surface papillary carcinoma. A clinicopathologic study of 10 cases and comparison with stage III-IV ovarian serous carcinoma.
SSPC was confined to the ovarian surface or showed focal minimal invasion and had a significantly worse prognosis than SOPC, as measured by median disease-free interval, median survival, and predicted 5-year survival.
Varieties of Serous Surface Papillary Carcinoma of the Peritoneum in Northern Germany: A Thirty‐Year Autopsy Study
  • D. Rothacker, G. Möbius
  • Medicine
    International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists
  • 1995
From a total of 62,858 autopsy files kept over a 30-year period, 57 cases of serous surface papillary carcinoma (SSPC) of the peritoneum were retrieved, significantly shorter than the survival rates at 1 year for SSPC in comparison with stages III and IV ovarian carcinomas.
Prognostic factors in extraovarian primary peritoneal carcinoma.
Overall survival in women with EOPPC is affected significantly by performance status and primary debulking surgery as independent variables, and efforts should be made to achieve optimal tumor cytoreduction at primary surgery.