Primary periodic paralyses

@article{Finsterer2008PrimaryPP,
  title={Primary periodic paralyses},
  author={Josef Finsterer},
  journal={Acta Neurologica Scandinavica},
  year={2008},
  volume={117}
}
  • J. Finsterer
  • Published 1 March 2008
  • Medicine, Political Science, Education
  • Acta Neurologica Scandinavica
Objective –  To review the current knowledge about primary periodic paralyses (PPs). 

Understanding the physiology of the asymptomatic diaphragm of the M1592V hyperkalemic periodic paralysis mouse

When muscles become paralyzed in crises of hyperkalemic periodic paralysis, patients do not stop breathing. Here is why.

Primary Periodic Paralyses: A Review of Etiologies and Their Pathogeneses

Periodic paralyses are a group of disorders characterized by episodes of muscle paralyses that occur as a result of mutations in genes encoding subunits of muscle membrane channel proteins such as sodium, calcium, and potassium channels.

The primary periodic paralyses: diagnosis, pathogenesis and treatment.

Periodic paralyses (PPs) are rare inherited channelopathies that manifest as abnormal, often potassium (K)-sensitive, muscle membrane excitability leading to episodic flaccid paralysis. Hypokalaemic

Muscle and Myotonic Diseases

Although the history and clinical examination remain the most effective way of diagnosing the presence of myopathy, increasingly the clinician has to rely on an understanding of muscle

Paralisia periódica hipocalêmica esporádica Sporadic hypokalemic periodic paralysis

A case of primary hypokalemic periodic paralysis in a 25-year-old patient is reported, and the clinical and laboratory parameters were typical.

Case 1: Transient quadriplegia in a teenager.

A 16-year-old female, previously in good health, awakened to marked weakness in her lower extremities, which progressed to involve her arms and neck over the course of the day, except for her ability

Paralisia Periódica Hipocalêmica Tipo 1: Envolvimento dos Canais de Cálcio Dependentes de Voltagem

Despite considerable progress, is still poorly understood pathophysiology of mutant genes in muscle channelopathies, such as periodic paralysis, making it necessary to direct efforts not only to detect new genes and new mutations that cause, but also for its pathophysiologic consequences.

Thyrotoxic Periodic Paralysis with Sensory Deficits in Young African American Male: A Case Report and Literature Review

An interesting case of thyrotoxic periodic paralysis in 32-year-old African American male, who presented with sudden onset weakness in the bilateral lower extremity and left upper extremity is presented.

Persisting fatigue and myalgia as the presenting features in a case of hypokalaemic periodic paralysis

A 9-year-old boy who developed hypokalaemic periodic paralysis following a prodrome of persistent fatigue and muscle aches associated with mildly elevated creatine kinase (CK) levels is reported.
...

References

SHOWING 1-10 OF 123 REFERENCES

The exercise test in periodic paralysis

Of 21 patients with clinically definite hypokalemic, hyperkalemic, or normokalemic periodic paralysis, 15 (71%) had a greater than normal increase in compound muscle action potential amplitude during

Randomized trials of dichlorphenamide in the periodic paralyses

DCP is effective in the prevention of episodic weakness in both HypoPP and PSPP, and significantly reduced attack rates relative to placebo in the Hypo PP subjects.

Hyperkalaemic periodic paralysis and anaesthesia

It is concluded from the experiences that with depletion of potassium before surgery, prevention of carbohydrate depletion, avoidance of potassium‐releasing anaesthetic drugs and maintenance of normothermia, patients with hyperkalaemic periodic paralysis can be anaesthetised without complications.

[Hyperkalemic periodic paralysis].

Muscle strength usually returns to normal between attacks, although many affected people continue to experience mild stiffness (myotonia), particularly in muscles of the face and hands.

Progressive myopathy in hyperkalemic periodic paralysis.

The authors' experience suggests that a progressive myopathy is as common in hyperkalemic periodic paralysis as it is in the hypokalemic disorder.

Thyrotoxic periodic paralysis and anesthesia report of a case and literature review.

Electrocardiographic Manifestations in Patients with Thyrotoxic Periodic Paralysis

Relatively rapid heart rate, high QRS voltage, and first‐degree AV block are important clues suggesting TPP in patients who present with hypokalemia and paralysis.

SCN4A-associated hypokalemic periodic paralysis merits a trial of acetazolamide

Primary hypokalemic periodic paralysis (HypoPP) is characterized by episodes of transient flaccid paralysis in association with reduced serum potassium levels, and a proportion of affected individuals have slowly progressive permanent weakness.

Subsequent morphological changes in periodic paralysis. A study of seven cases.

Muscle biopsies were studied in patients with various types of periodic paralysis to suggest that histology may be normal early in the disease and degenerative changes are correlated with the presence of permanent myopathic weakness.

Thyrotoxic periodic paralysis in a Hispanic man after the administration of prednisone.

  • Zhaoe LiuL. BravermanA. Malabanan
  • Medicine
    Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
  • 2006
In a 34-year-old Hispanic man with TPP, the onset of the attack was not prevented by the use of propranolol and was likely triggered by the administration of prednisone.
...