Primary palmar hyperhidrosis locus maps to 14q11.2‐q13

@article{Higashimoto2006PrimaryPH,
  title={Primary palmar hyperhidrosis locus maps to 14q11.2‐q13},
  author={Ikuyo Higashimoto and Koh-ichiro Yoshiura and Naomi Hirakawa and Ken Higashimoto and Hidenobu Soejima and Tadahide Totoki and Tsunehiro Mukai and Norio Niikawa},
  journal={American Journal of Medical Genetics Part A},
  year={2006},
  volume={140A}
}
Primary palmar hyperhidrosis (PPH) is a unique disorder of unknown cause. It is characterized by excessive perspiration of the eccrine sweat gland in the palm, sole, and the axilla. It is presumed that PPH results from overactivation of the cholinergic sympathetic nerve or dysfunction of the autonomic nervous system. There have been no genetic studies on the disease. We performed a linkage analysis of 11 families including 42 affected and 40 unaffected members using genome‐wide DNA polymorphic… Expand
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[Hyperhidrosis-aetiopathogenesis, diagnosis, clinical symptoms and treatment].
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  • 2018
TLDR
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Preliminary studies suggest that surgery may also play an effective role in the management of craniofacial and plantar HH. Expand
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  • Journal of the European Academy of Dermatology and Venereology : JEADV
  • 2012
TLDR
The challenge for the dermatologist remains to evaluate the severity of hyperhidrosis to achieve the best therapeutic outcome, this can be done most effectively using the Hyperhidrosis Disease Severity Scale (HDSS). Expand
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Examination of pedigrees of patients with primary hyperhidrosis demonstrated a sibling recurrence risk of λs = 29–48 and an offspring recurrencerisk ofλo = 41–68 indicating thathyperhidrosis can be an inherited condition, and the pattern of inheritance suggests an autosomal dominant mode of transmission. Expand
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TLDR
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