Primary ovarian insufficiency: autoimmune causes.

  title={Primary ovarian insufficiency: autoimmune causes.},
  author={Antonio La Marca and Annalisa Brozzetti and Giovanna Sighinolfi and Stefania Marzotti and Annibale Volpe and Alberto Falorni},
  journal={Current opinion in obstetrics & gynecology},
  volume={22 4},
PURPOSE OF REVIEW To review the pathogenesis of premature ovarian insufficiency due to steroid cell autoimmunity (SCA-POI). RECENT FINDINGS Autoimmune oophoritis is characterized by a selective mononuclear cell infiltration into the theca layer of large, antral follicles, with earlier stage follicles consistently free of lymphocytic infiltration. SCA-POI is caused by the selective autoimmune destruction of theca cells with preservation of granulosa cells that produce low amounts of estradiol… CONTINUE READING
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