Primary ovarian insufficiency: autoimmune causes.

@article{Marca2010PrimaryOI,
  title={Primary ovarian insufficiency: autoimmune causes.},
  author={Antonio la Marca and Annalisa Brozzetti and Giovanna Sighinolfi and Stefania Marzotti and Annibale Volpe and Alberto Falorni},
  journal={Current opinion in obstetrics & gynecology},
  year={2010},
  volume={22 4},
  pages={
          277-82
        }
}
  • Antonio la Marca, Annalisa Brozzetti, +3 authors Alberto Falorni
  • Published in
    Current opinion in obstetrics…
    2010
  • Medicine
  • PURPOSE OF REVIEW To review the pathogenesis of premature ovarian insufficiency due to steroid cell autoimmunity (SCA-POI). RECENT FINDINGS Autoimmune oophoritis is characterized by a selective mononuclear cell infiltration into the theca layer of large, antral follicles, with earlier stage follicles consistently free of lymphocytic infiltration. SCA-POI is caused by the selective autoimmune destruction of theca cells with preservation of granulosa cells that produce low amounts of estradiol… CONTINUE READING

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