Primary ovarian cancer cultures are resistant to Fas-mediated apoptosis.


OBJECTIVES Fas, a primary mediator of cellular apoptosis, is expressed by the normal ovarian epithelium. We analyzed the levels of Fas and soluble Fas (sFas) expression in ovarian cancer tissue and determined the susceptibility of primary ovarian cancer cell (CSOC) cultures to Fas-mediated apoptosis. METHODS Fas mRNA levels were detected by RT-PCR, and… (More)