Primary osteoarthritis no longer primary: three subsets with distinct etiological, clinical, and therapeutic characteristics.

@article{HerreroBeaumont2009PrimaryON,
  title={Primary osteoarthritis no longer primary: three subsets with distinct etiological, clinical, and therapeutic characteristics.},
  author={G Herrero-Beaumont and Jorge A. Rom{\'a}n-Blas and Santos Casta{\~n}eda and Sergio A Jimenez},
  journal={Seminars in arthritis and rheumatism},
  year={2009},
  volume={39 2},
  pages={71-80}
}
BACKGROUND Osteoarthritis (OA) has been historically divided into primary and secondary. Primary OA has been defined as an idiopathic condition developing in previously undamaged joints in the absence of an obvious causative mechanism. During the last few years a large amount of evidence has provided new insights into the biochemistry and molecular biology of cartilage, subchondral bone, and other articular tissues, which suggest distinct etiopathogenetic mechanisms in some forms of primary OA… CONTINUE READING