Primary myotubes preferentially mature into either the fastest or slowest muscle fibers.

Abstract

Myoblasts and myotubes are heterogeneous, but what is the significance of this heterogeneity? Is it a vital component of the mechanism by which a muscle develops or is it part of the process that generates mature fibers with diverse sizes, speeds of contracture, and metabolisms? We have begun to explore these questions by using BrdU to selectively label rat… (More)

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