Primary myelofibrosis with or without mutant MPL: comparison of survival and clinical features involving 603 patients

@article{Pardanani2011PrimaryMW,
  title={Primary myelofibrosis with or without mutant MPL: comparison of survival and clinical features involving 603 patients},
  author={Animesh Pardanani and Paola Guglielmelli and Terra L. Lasho and Alessandro Pancrazzi and Christy M. Finke and Alessandro Maria Vannucchi and Ayalew Tefferi},
  journal={Leukemia},
  year={2011},
  volume={25},
  pages={1834-1839}
}
MPL and JAK2V617F mutation analysis was performed in 603 patients with primary myelofibrosis (PMF) seen at the Mayo Clinic, USA (n=329) or University of Florence, Italy (n=274). Mutant MPL was detected in 49 (8.1%) patients and JAK2V617F in 350 (58%); 4 patients showed both mutations. MPLW515L/K was the commonest mutation; 2 patients showed novel mutations (L513ins and Q516-P518insAAAA). The US and Italy patient cohorts were separately analyzed for comparison of survival and clinical features… CONTINUE READING

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MPLW 515 L mutation in acute megakaryoblastic leukaemia

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