Primary myelofibrosis: 2014 update on diagnosis, risk‐stratification, and management

@article{Tefferi2014PrimaryM2,
  title={Primary myelofibrosis: 2014 update on diagnosis, risk‐stratification, and management},
  author={A. Tefferi},
  journal={American Journal of Hematology},
  year={2014},
  volume={89}
}
  • A. Tefferi
  • Published 2014
  • Medicine
  • American Journal of Hematology
Disease overview: Primary myelofibrosis (PMF) is a myeloproliferative neoplasm characterized by stem cell‐derived clonal myeloproliferation, abnormal cytokine expression, bone marrow fibrosis, anemia, splenomegaly, extramedullary hematopoiesis (EMH), constitutional symptoms, cachexia, leukemic progression, and shortened survival. Diagnosis: Diagnosis is based on bone marrow morphology. The presence of JAK2, CALR, or MPL mutation is supportive but not essential for diagnosis; approximately 90… Expand
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