Primary mouse myoblast purification, characterization, and transplantation for cell-mediated gene therapy

  • T A Rando, Helen M. Blau
  • Published 1994 in The Journal of cell biology
The transplantation of cultured myoblasts into mature skeletal muscle is the basis for a new therapeutic approach to muscle and non-muscle diseases: myoblast-mediated gene therapy. The success of myoblast transplantation for correction of intrinsic muscle defects depends on the fusion of implanted cells with host myofibers. Previous studies in mice have… (More)