Primary metastatic osteosarcoma: presentation and outcome of patients treated on neoadjuvant Cooperative Osteosarcoma Study Group protocols.

@article{Kager2003PrimaryMO,
  title={Primary metastatic osteosarcoma: presentation and outcome of patients treated on neoadjuvant Cooperative Osteosarcoma Study Group protocols.},
  author={Leo Kager and Andreas Zoubek and Ulrike Poetschger and Ulrike Kastner and Silke Flege and Beate Kempf-Bielack and Detlev Branscheid and Rainer Kotz and Mechthild Salzer-Kuntschik and Winfried Winkelmann and Gernot Jundt and Hartmut Kabisch and Peter Reichardt and Heribert J{\"u}rgens and Helmut Gadner and Stefan S. Bielack},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  year={2003},
  volume={21 10},
  pages={2011-8}
}
PURPOSE To determine demographic data and define prognostic factors for long-term outcome in patients presenting with high-grade osteosarcoma of bone with clinically detectable metastases at initial presentation. PATIENTS AND METHODS Of 1,765 patients with newly diagnosed, previously untreated high-grade osteosarcomas of bone registered in the neoadjuvant Cooperative Osteosarcoma Study Group studies before 1999, 202 patients (11.4%) had proven metastases at diagnosis and therefore were… CONTINUE READING