Primary mast cell disorders in children.

  title={Primary mast cell disorders in children.},
  author={Ari J. Fried and Cem Akin},
  journal={Current allergy and asthma reports},
  volume={13 6},
Mastocytosis arises from clonal mast cell expansion and the resultant accumulation of mast cells in cutaneous and sometimes extracutaneous tissues. Recent studies have demonstrated that c-kit mutations seem to be more prevalent in pediatric mastocytosis than previously assumed, but what determines disease evolution and severity in the individual patient remains elusive. For the large majority of children, mastocytosis is a self-limited cutaneous disease that spontaneously regresses before they… CONTINUE READING
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