Primary malignant neoplasms of the appendix

  title={Primary malignant neoplasms of the appendix},
  author={Margaret Elizabeth McCusker and Timothy R. Cot{\'e} and Limin X. Clegg and Leslie Sobin},
Cancer of the appendix is an uncommon disease that is rarely suspected rarely before surgery. Although several case series of these tumors have been published, little research has been anchored in population‐based data on cancer of the appendix. 

Surgical treatment of malignant carcinoid tumours of the appendix

Since their first description in 1882, malignant neoplasm of the appendix still remain rare, and precise treatment protocols for these neoplasms remain unclear, so published evidence is searched to produce management guidelines.

Carcinoid tumors of the appendix: A population‐based study

Carcinoid tumors of the appendix are rare, and as such there are few data guiding their optimal treatment.

Goblet Cell Carcinoids of the Appendix

The diagnosis, pathology and management of goblet cell carcinoid of the appendix using an illustrative case history is reviewed.


A case of adenocarcinoma of the appendix is presented in a case initially treated as acute appendicitis.

Varying malignant potential of appendiceal neuroendocrine tumors: Importance of histologic subtype

Neuroendocrine tumors (NETs) of the appendix include malignant carcinoid tumor (MCT), goblet cell carcinoid (GCT), and composite goblet cell carcinoid‐adenocarcinoma (CGCC‐A).

Clinical characteristics and prognostic factors for primary appendiceal carcinoma

Primary adenocarcinoma of the appendix is a rare malignancy and prognostic factors affecting the clinical outcome in patients with appendiceal neoplasms are assessed.

Carcinoid tumour of the appendix

Controversy exists over the management following appendicectomy, especially with regard to the role of right hemicolectomy in patients with tumours smaller than 2 cm in diameter.

Treatment patterns and outcomes in goblet cell carcinoid tumors of the appendix

This work aims to examine the overall survival per stage and the relationship between different treatment modalities and outcomes for patients with GCC tumors of the appendix.



An analysis of 8305 cases of carcinoid tumors

Carcinoid tumors are unusual and most reports are anecdotal or limited in number. A series of 2837 cases was published in 1975. No recent large series is available.

Epithelial noncarcinoid tumors and tumor‐like lesions of the appendix. A clinicopathologic study of 184 patients with a multivariate analysis of prognostic factors

The aim of this study was to perform clinicopathologic correlation, particularly concerning prognosis, on a relatively large series of patients with epithelial tumors and tumor‐like lesions of the human vermiform appendix.

Unusual tumors of the appendix and pseudomyxoma peritonei.

This report covers hyperplastic and neoplastic lesions of the human vermiform appendix that, although unusual, are likely to be encountered by general surgical pathologists. Topics include epithelial

Primary carcinoma of the vermiform appendix.

The Natural History of Surgically Treated Primary Adenocarcinoma of the Appendix

Primary adenocarcinoma of the appendix should be treated by right hemicolectomy, even if it is a secondary procedure, and surveillance for synchronous or metachronous tumors, especially in the gastrointestinal tract, is warranted.

Appendiceal malignancies.

  • A. Lyss
  • Medicine
    Seminars in oncology
  • 1988
Treatment and prognosis are markedly different for each of the histologic variants of appendiceal malignancy, and there is evidence that adenocarcinoids develop from simultaneous neoplastic change in two stem cell populations.

[Goblet cell carcinoid of the appendix].

Because of the relatively large size of the tumor and neoplastic invasion to the mesoappedix in this case and, in addition, the possible malignant nature of carcinoid tumor, ileoascendocolectomy was performed as an additional operation.

Management and prognosis of adenocarcinoma of the appendix

Good prognostic factors include mucinous histology and the absence of carcinomatosis and right hemicolectomy appears to be a reasonable option, although its superiority to appendectomy alone has not been definitively proven.

Adenocarcinoma of the vermiform appendix. A population study

In none of the authors' patients was the diagnosis made preoperatively and no tumors were found in appendices removed incidental to other intra‐abdominal operations, and the incidence of adenocarcinoma of the vermiform appendix in Iceland during 1974–1989 was approximately 0.2 cases/100.000/year.

Adenocarcinoid, a mucin‐producing carcinoid tumor of the appendix. A study of 39 cases

Most adenocarcinoids can be adequately treated by appendectomy, but hemicolectomy is recommended for those tumors showing atypical foci, a high mitotic count, or spread beyond the appendix.