Primary insulin insufficiency after blocking of zinc in pancreatic beta-cells.
@article{Lazaris1981PrimaryII,
title={Primary insulin insufficiency after blocking of zinc in pancreatic beta-cells.},
author={Jacob Lazaris and Z E Bavelskyi},
journal={Endocrinologia experimentalis},
year={1981},
volume={15 2},
pages={
99-109
}
}Diabetogenic effects of various analogues of 8-aminoquinoline were studied. Out of 10 compounds investigated only three showed diabetogenic properties: 8-(p-tolylsulfonylamino)-quinoline, 8-(p-benzenesulfonylamino)-quinoline and 8-(p-methylsulfonylamino)-quinoline. After the injection of these compounds a long term persistent hyperglycemia took place in rabbits and also degenerative changes of insulin producing cells in pancreatic islets were found. All above compounds form stable complexes… Expand