Primary hyperhidrosis

  title={Primary hyperhidrosis
  author={Horacio Kaufmann and Daniela Saadia and Charlene Polin and Stephen Hague and Amanda Singleton and Andrew Singleton},
  journal={Clinical Autonomic Research},
Abstract. Primary hyperhidrosis is a neurogenic disorder of unknown cause characterized by excessive sweating in the palmar surface of the hands, armpits, groin and feet. In the course of a therapeutic trial for primary hyperhidrosis, 62 % of patients reported a positive family history. Examination of these pedigrees demonstrated a sibling recurrence risk of λs = 29–48 and an offspring recurrence risk of λo = 41–68 indicating that hyperhidrosis can be an inherited condition. The pattern of… 
Treatment of Secondary Hyperhidrosis -A report of three cases-
Three cases of secondary hyperhidrosis following systemic disease and trauma, which were treated with systemic or topical anticholinergics were experienced.
[Hyperhidrosis-aetiopathogenesis, diagnosis, clinical symptoms and treatment].
  • J. Wohlrab, B. Kreft
  • Medicine
    Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete
  • 2018
Primary hyperhidrosis is a complex neuropathic dysregulation with a genetic predisposition and is diagnosed when patients show pathologic sweating patterns and excessive sweating for at least 6 months and fulfill at least four of the following criteria.
Treatment of Hand Eczema Caused by Hyperhidrosis
Treatment modalities for hyperhidrosis include topical antiperspirants, iontophoresis, botulinum toxin A injections, systemic anticholinergics, and surgical denervation of the thoracic sympathetic chain.
Plantar Hyperhidrosis: An Overview.
  • T. Vlahovic
  • Medicine
    Clinics in podiatric medicine and surgery
  • 2016
Diagnosis and treatment of primary hyperhidrosis.
The most common form of focal hyperhidrosis is excessive sweating localized mainly on the surface of palms or feet, which is associated with significant reduction of life quality resulting from impairment of daily activities, social interactions and professional activities.
Analysis of family history of palmoplantar hyperhidrosis in Japan
Pedigree charts prepared based on data obtained by patient interviews suggested autosomal dominant inheritance in parent–child cases and the incidence of PPH in three generations was 13%.
Genetic disposition to primary hyperhidrosis: a review of literature
It seems that primary hyperhidrosis is polygenically inherited, and considering the impairment, further data to understand the genetic etiology of the disease are needed.
Primary palmar hyperhidrosis locus maps to 14q11.2‐q13
A linkage analysis of 11 families including 42 affected and 40 unaffected members using genome‐wide DNA polymorphic markers to identify the primary palmar hyperhidrosis locus supported that one of the PPH locus is assigned at minimum to about a 6‐cM interval between D14S1070 andD14S990 and at maximum to about about a 30‐ cM intervals between D 14S10 70 and D14 S70.
Botulinum Toxin for Hyperhidrosis
Recent evidence suggests that botulinum toxin type A (BTX-A) injections into hyperhidrotic areas can considerably reduce focal sweating in multiple areas without major adverse effects, and BTx-A has therefore shown promise as a potential replacement for more invasive treatments after topical aluminum salts have failed.


Pachyonychia congenita with laryngeal involvement.
Palmar hyperhidrosis: evidence of genetic transmission.
It is concluded that primary palmar hyperhidrosis is a hereditary disorder, with variable penetrance and no proof of sex-linked transmission, and may lead to earlier diagnoses and advances in medical and psychosocial interventions.
Palmar-plantar hyperhidrosis occurring in a kindred with nail-patella syndrome.
Emotional eccrine sweating. A heritable disorder.
A family with hereditary emotional hyperhidrosis is described and of two family members tested, both had a marked decrease in palmar sweat secretion during administration of diltiazem, a calcium-channel blocker.
Current therapeutic strategies for hyperhidrosis: a review.
It can be stated that in spite of the interesting and promising new alternatives, especially using botulinum toxin, the tried-and-true procedures such as tap water iontophoresis and aluminium chloride salts still have a firm place in the treatment of hyperhidrosis.
Botulinum toxin type A in primary palmar hyperhidrosis
Both 50 and 100 U of botulinum toxin type A, injected intradermally in each hand, decreased sweating in patients with primary hyperhidrosis for at least 2 months in all the patients, and 6 months in most patients.
Mal de Meleda without mutations in the ARS coding sequence.
A patient suffering from Mal de Meleda not associated with ARS mutations is reported, and the related E48 and GML genes were also excluded.
Endoscopic transthoracic sympathectomy for idiopathic upper limb hyperhidrosis
This procedure was successful in curing or improving intractable sweating in 92%.
Twins and their mildly affected mother with Weaver syndrome
Twins and their mildly affected mother with Weaver syndrome and the parents of twins affected by Weaver syndrome, 1993.