Primary human herpesvirus 8 infection generates a broadly specific CD8(+) T-cell response to viral lytic cycle proteins.

@article{Wang2001PrimaryHH,
  title={Primary human herpesvirus 8 infection generates a broadly specific CD8(+) T-cell response to viral lytic cycle proteins.},
  author={Q J Wang and Frank J. Jenkins and Lisa Paula Jacobson and L A Kingsley and R D Day and Z W Zhang and Y X Meng and Philip E. Pellett and Konstantin Gus Kousoulas and A Baghian and Charles R. Rinaldo},
  journal={Blood},
  year={2001},
  volume={97 8},
  pages={2366-73}
}
Human herpesvirus 8 (HHV-8) is a recently discovered gammaherpesvirus that is the etiologic agent of Kaposi sarcoma (KS). The natural history of primary HHV-8 infection, including clinical outcome and host immune responses that may be important in preventing disease related to HHV-8, has not been elucidated. The present study characterized the clinical, immunologic, and virologic parameters of primary HHV-8 infection in 5 cases detected during a 15-year longitudinal study of 108 human… CONTINUE READING