Primary human CD34+ hematopoietic stem and progenitor cells express functionally active receptors of neuromediators.

  title={Primary human CD34+ hematopoietic stem and progenitor cells express functionally active receptors of neuromediators.},
  author={Ulrich G. Steidl and Simone Bork and Sebastian Schaub and Oliver Selbach and Janette {\vS}ere{\vs} and Manuel A Aivado and Thomas Schroeder and Ulrich Peter Rohr and Roland Fenk and Slawomir Kliszewski and Christian Maercker and Peter Neubert and Stefan R. Bornstein and Helmut L. Haas and Guido Kobbe and Daniel Geoffrey Tenen and Rainer Haas and Ralf Kronenwett},
  volume={104 1},
Recently, overlapping molecular phenotypes of hematopoietic and neuropoietic cells were described in mice. Here, we examined primary human CD34(+) hematopoietic stem and progenitor cells applying specialized cDNA arrays, real-time reverse-transcriptase-polymerase chain reaction (RT-PCR), and fluorescent-activated cell sorter (FACS) analysis focusing on genes involved in neurobiologic functions. We found expression of vesicle fusion and motility genes, ligand- and voltage-gated ion channels… 

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