Primary human CD34+ hematopoietic stem and progenitor cells express functionally active receptors of neuromediators.

@article{Steidl2004PrimaryHC,
  title={Primary human CD34+ hematopoietic stem and progenitor cells express functionally active receptors of neuromediators.},
  author={Ulrich Steidl and Simone Bork and Sebastian Schaub and Oliver Selbach and Janette Seres and Manuel A Aivado and Thomas Schroeder and U Rohr and Roland Fenk and Slawomir Kliszewski and Christian Maercker and Peter Neubert and Stefan R. Bornstein and Helmut L. Haas and Guido Kobbe and Daniel G Tenen and Rainer Haas and Ralf Kronenwett},
  journal={Blood},
  year={2004},
  volume={104 1},
  pages={
          81-8
        }
}
Recently, overlapping molecular phenotypes of hematopoietic and neuropoietic cells were described in mice. Here, we examined primary human CD34(+) hematopoietic stem and progenitor cells applying specialized cDNA arrays, real-time reverse-transcriptase-polymerase chain reaction (RT-PCR), and fluorescent-activated cell sorter (FACS) analysis focusing on genes involved in neurobiologic functions. We found expression of vesicle fusion and motility genes, ligand- and voltage-gated ion channels… CONTINUE READING

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