Primary hepatocytes from mice lacking cysteine dioxygenase show increased cysteine concentrations and higher rates of metabolism of cysteine to hydrogen sulfide and thiosulfate

@article{Jurkowska2014PrimaryHF,
  title={Primary hepatocytes from mice lacking cysteine dioxygenase show increased cysteine concentrations and higher rates of metabolism of cysteine to hydrogen sulfide and thiosulfate},
  author={Halina Jurkowska and Heather B. Roman and Lawrence L. Hirschberger and Kiyoshi Sasakura and Tomoyuki Nagano and Kenjiro Hanaoka and Jakub Krijt and Martha H. Stipanuk},
  journal={Amino Acids},
  year={2014},
  volume={46},
  pages={1353-1365}
}
The oxidation of cysteine in mammalian cells occurs by two routes: a highly regulated direct oxidation pathway in which the first step is catalyzed by cysteine dioxygenase (CDO) and by desulfhydration-oxidation pathways in which the sulfur is released in a reduced oxidation state. To assess the effect of a lack of CDO on production of hydrogen sulfide (H2S) and thiosulfate (an intermediate in the oxidation of H2S to sulfate) and to explore the roles of both cystathionine γ-lyase (CTH) and… CONTINUE READING
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