Primary hepatocyte cultures for pharmaco-toxicological studies: at the busy crossroad of various anti-dedifferentiation strategies

@article{Fraczek2012PrimaryHC,
  title={Primary hepatocyte cultures for pharmaco-toxicological studies: at the busy crossroad of various anti-dedifferentiation strategies},
  author={Joanna Fraczek and Jennifer Bolleyn and Tamara Vanhaecke and Vera Rogiers and Mathieu Vinken},
  journal={Archives of Toxicology},
  year={2012},
  volume={87},
  pages={577-610}
}
Continuously increasing understanding of the molecular triggers responsible for the onset of diseases, paralleled by an equally dynamic evolution of chemical synthesis and screening methods, offers an abundance of pharmacological agents with a potential to become new successful drugs. However, before patients can benefit of newly developed pharmaceuticals, stringent safety filters need to be applied to weed out unfavourable drug candidates. Cost effectiveness and the need to identify compound… CONTINUE READING

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