Primary glioblastomas express mesenchymal stem-like properties.

  title={Primary glioblastomas express mesenchymal stem-like properties.},
  author={C L Tso and Peter I. Shintaku and James Chen and Qinghai Liu and Jason B Liu and Zugen Chen and Koji Yoshimoto and Paul Mischel and Timothy F. Cloughesy and L M Liau and Stanley F. Nelson},
  journal={Molecular cancer research : MCR},
  volume={4 9},
Glioblastoma is the most common and aggressive primary brain cancer. Recent isolation and characterization of brain tumor-initiating cells supports the concept that transformed neural stem cells may seed glioblastoma. We previously identified a wide array of mesenchymal tissue transcripts overexpressed in a broad set of primary glioblastoma (de novo) tumors but not in secondary glioblastoma (derived from lower-grade) tumors, low-grade astrocytomas, or normal brain tissues. Here, we extend this… CONTINUE READING


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