Primary cutaneous T-cell lymphomas show a deletion or translocation affecting NAV3, the human UNC-53 homologue.

@article{Karenko2005PrimaryCT,
  title={Primary cutaneous T-cell lymphomas show a deletion or translocation affecting NAV3, the human UNC-53 homologue.},
  author={Leena Karenko and Sonja Hahtola and Suvi P{\"a}ivinen and Ritva Karhu and Sanna Syrj{\"a} and Marketta K{\"a}hk{\"o}nen and Boguslaw Nedoszytko and Soili Kyt{\"o}l{\"a} and Ying Zhou and Vesna Blazevic and Maria Pesonen and Hanna Nevala and Nina N. Nupponen and Harri Sihto and Inge Krebs and Annemarie Poustka and Jadwiga Roszkiewicz and Kalle Saksela and P{\"a}rt Peterson and Tapio Visakorpi and Annamari Ranki},
  journal={Cancer research},
  year={2005},
  volume={65 18},
  pages={8101-10}
}
Multicolor fluorescent in situ hybridization (FISH) was used to identify acquired chromosomal aberrations in 12 patients with mycosis fungoides or Sézary syndrome, the most common forms of primary cutaneous T-cell lymphoma (CTCL). The most frequently affected chromosome was 12, which showed clonal deletions or translocations with a break point in 12q21 or 12q22 in five of seven consecutive Sézary syndrome patients and a clonal monosomy in the sixth patient. The break point of a balanced… CONTINUE READING
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