Primary ciliary dyskinesia in mice lacking the novel ciliary protein Pcdp1.

@article{Lee2008PrimaryCD,
  title={Primary ciliary dyskinesia in mice lacking the novel ciliary protein Pcdp1.},
  author={Lance Lee and Dean R Campagna and Jack L. Pinkus and Howard L Mulhern and Todd A Wyatt and Joseph H. Sisson and Jacqueline A. Pavlik and Geraldine S. Pinkus and Mark D Fleming},
  journal={Molecular and cellular biology},
  year={2008},
  volume={28 3},
  pages={949-57}
}
Primary ciliary dyskinesia (PCD) results from ciliary dysfunction and is commonly characterized by sinusitis, male infertility, hydrocephalus, and situs inversus. Mice homozygous for the nm1054 mutation develop phenotypes associated with PCD. On certain genetic backgrounds, homozygous mutants die perinatally from severe hydrocephalus, while mice on other backgrounds have an accumulation of mucus in the sinus cavity and male infertility. Mutant sperm lack mature flagella, while respiratory… CONTINUE READING

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