Primary cerebral blood flow deficiency and Alzheimer's disease: shadows and lights.

@article{Mazza2011PrimaryCB,
  title={Primary cerebral blood flow deficiency and Alzheimer's disease: shadows and lights.},
  author={Marianna Mazza and Giuseppe Marano and Gianandrea Traversi and Pietro Bria and S Fernando Mazza},
  journal={Journal of Alzheimer's disease : JAD},
  year={2011},
  volume={23 3},
  pages={
          375-89
        }
}
Alzheimer's disease (AD) is a degenerative disorder characterized by a decreased regional cerebral blood flow (CBF). It is most likely that a reduction in CBF could displace a pathway leading to AD genesis, in so far neuron death explains a sustained reduction in the supply of oxygen, glucose, and nutrients. Nevertheless, the concept of secondary CBF deficiency cannot explain the critical stages of early memory loss while, on the other hand, the picture of progressive ischemia due to primary… CONTINUE READING
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