Primary biliary cirrhosis. A patient with adverse reactions to tiopronin and autoimmune hemolytic anemia with reticulocytopenia.

@article{Shichiri1984PrimaryBC,
  title={Primary biliary cirrhosis. A patient with adverse reactions to tiopronin and autoimmune hemolytic anemia with reticulocytopenia.},
  author={Motoaki Shichiri and Wasaku Koyama and Shinichi Tozuka and Sadaaki Sakamoto and Manabu Kanayama},
  journal={Archives of internal medicine},
  year={1984},
  volume={144 1},
  pages={89-91}
}
A 32-year-old woman with asymptomatic primary biliary cirrhosis had autoimmune hemolytic anemia associated with reticulocytopenia and thrombocytopenia despite an intensely erythroid bone marrow. Her anemia was successfully treated with oral prednisolone and intravenous pulse methylprednisolone, with a rapid response of reticulocytosis and sustained erythrocytosis. Tiopronin therapy was later initiated and resulted in fever, rash, exacerbation of the liver disease, and positive direct and… CONTINUE READING