Primary and secondary progressive multiple sclerosis

  title={Primary and secondary progressive multiple sclerosis},
  author={Sandra Vukusic and Christian Confavreux},
  journal={Journal of the Neurological Sciences},
Insight into the pathogenesis of primary progressive multiple sclerosis aid in understanding the processes that drive progression in all forms of MS.
Progressive multiple sclerosis: characteristics and management.
  • K. Hawker
  • Psychology, Medicine
    Neurologic clinics
  • 2011
The complex etiology of multiple sclerosis.
Progressive Multiple Sclerosis
None of the therapies currently approved for use in relapsing-remitting MS have been shown to slow the gradual progression of disability that occurs in the absence of recent relapses or changes in MRI.
Multiple Sclerosis in the Elderly Patient
The characteristics of senescent AOMS and LOMS patients are outlined and therapeutic strategies in elderly patients with MS are discussed based on the knowledge of immunosenescence and age-associated characteristics of this disorder.
NF-B , a Potential Therapeutic Target for the Treatment of Multiple Sclerosis
The role of NFB will be reviewed and its potential as a new therapeutic target in MS will be considered and compared with existing treatments.
NF-kappa B, a potential therapeutic target for the treatment of multiple sclerosis.
  • J. YanJ. Greer
  • Biology, Psychology
    CNS & neurological disorders drug targets
  • 2008
The role of NF-kappaB in MS is reviewed and its potential as a new therapeutic target in MS will be considered and compared with existing treatments.
Natural history of multiple sclerosis: risk factors and prognostic indicators
Overall course and prognosis in multiple sclerosis is most likely to be related to age and the occurrence of the progressive phase of the disease, rather than to relapses or other clinical parameters.
Association of Inflammation and Disability Accrual in Patients With Progressive-Onset Multiple Sclerosis
In progressive-onset MS, superimposed relapses are associated with a lower risk of confirmed disability progression and the findings suggest that inflammatory relapse are an important and modifiable determinant of disability accrual in progressive-ONSet disease.
Multiple sclerosis with a progressive course from onset in Lorraine-Eastern France
There were no significant differences in the demographic data and clinical data between the patients with PPMS and PRMS suggesting such a distinction may be unnecessary and any significant unfluence of sex, age at onset, or symptoms at onset on the time from MS onset to assignment of scores 6 or 7 was not found.


Primary progressive multiple sclerosis: a distinct syndrome?
The proposition that primary progressive MS has a prof ile distinct from other MS categories is evaluated, contrasting the separate differential diagnoses and examining the implications for future therapeutic trials.
Primary progressive multiple sclerosis.
The mechanisms underlying the development of disability and the role of MRI in monitoring disease activity in this clinical subgroup require elucidation, particularly in view of the lack of change on conventional imaging in the presence of continuing clinical deterioration.
A comparison of the pathology of primary and secondary progressive multiple sclerosis.
There was significantly more inflammation in secondarygressive multiple sclerosis (as judged by the frequency of perivascular cuffing and cellularity of the parenchyma) than in primary progressive disease, which has implications for therapeutic strategies in progressive multiple sclerosis.
Course and prognosis of chronic progressive multiple sclerosis: Results of an epidemiological study
Determining the “year of progression” seems to be significant for the prognosis of multiple sclerosis, and progression of the handicap was most rapid in case of a secondary progressive course, female sex, high relapse rate in the preceding remitting phase and “ year ofgression” at a higher age.
Diagnostic criteria for primary progressive multiple sclerosis: A position paper
New diagnostic criteria developed by a group of investigators on the basis of a review of their considerable experience with primary progressive multiple sclerosis require prospective validation in a cohort of newly diagnosed patients and by postmortem examination.
Multiple sclerosis that is progressive from the time of onset: clinical characteristics and progression of disability.
The clinical characteristics and disability progression of these MS subtypes were indistinguishable, with the exception of 1 or 2 relapses in patients with PRMS that occurred 8 months to 9 years after the onset of symptoms.
The natural history of multiple sclerosis: a geographically based study. 5. The clinical features and natural history of primary progressive multiple sclerosis.
From clinical onset, rate of progression was faster in the PP- multiple sclerosis group than in the secondary progressive (SP)-multiple sclerosis group, and when the rates of progression from onset of the progressive phase to DSS 6, 8 and 10 were compared, SP-multiple sclerosis had a more rapid progressive phase.
Major differences in the dynamics of primary and secondary progressive multiple sclerosis
Findings may indicate a difference in the dynamics of disease activity between the two forms of progressive MS, particularly in relation to the inflammatory component of the lesions, and have important implications for the selection of patients and the monitoring of diseaseactivity in therapeutic trials.
The natural history of multiple sclerosis: a geographically based study. 7. Progressive-relapsing and relapsing-progressive multiple sclerosis: a re-evaluation.
The validity of the terms 'RP' and 'PR' multiple sclerosis is evaluated in the context of long-term outcome within a large population-based cohort of progressive multiple sclerosis patients seen at the London Multiple Sclerosis Clinic between 1972 and 1984 and provides justification for retaining only PP and SP multiple sclerosis as the subgroups of progressive disease.
Early prognostic factors for disability in multiple sclerosis, a European multicenter study
In the whole remittent group the presence of pyramidal and cerebellar symptoms at onset predicted both a high disability score and a rapid shift to a secondary progression, while the effect was reverse for sensory and visual symptoms.