Primary and Secondary Immunodeficiency Pyogenic Bacterial Infections in Humans With MyD88 Deficiency

  • Bernuth H Picard, Jin Z, James E Gern, Llobet Mp
  • Published 2009

Abstract

PURPOSE OF THE STUDY. Myeloid differentiation protein 88 (MyD88) is a key downstream adapter for receptors of the innate immune system, including most Toll-like receptors (TLRs) and interleukin 1 receptors (IL-1Rs). MyD88 deficiency in mice leads to susceptibility to a broad range of pathogens, and the goal of this study was to determine whether there are… (More)

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