Primary and Secondary Cell Death in Human Melanoma Xenografts following Hyperthermic Treatment1

Abstract

The response to hyperthermic treatment (42.5°Cfor 60 min) of 5 human malignant melanomas grown in athymic mice (BALB/ c/nu/nu/BOM) was studied. Local hyperthermia was given by immersing the tumor-bearing leg of the mice into a thermostati cally regulated water bath. Growth delay studies indicated that the melanomas were different in heat responsiveness… (More)

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