Primary and Chronic HIV Infection Differently Modulates Mucosal Vδ1 and Vδ2 T-Cells Differentiation Profile and Effector Functions

@inproceedings{Cimini2015PrimaryAC,
  title={Primary and Chronic HIV Infection Differently Modulates Mucosal Vδ1 and Vδ2 T-Cells Differentiation Profile and Effector Functions},
  author={Eleonora Cimini and Chiara Agrati and Gianpiero D’Offizi and Chrysoula Vlassi and Rita Casetti and Alessandra Sacchi and Raffaella Lionetti and Veronica Bordoni and Nicola Tumino and Paola Scognamiglio and Federico Martini and Matthias Eberl},
  booktitle={PloS one},
  year={2015}
}
Gut-associated immune system has been identified as a major battlefield during the early phases of HIV infection. γδ T-cells, deeply affected in number and function after HIV infection, are able to act as a first line of defence against invading pathogens by producing antiviral soluble factors and by killing infected cells. Despite the relevant role in mucosal immunity, few data are available on gut-associated γδ T-cells during HIV infection. Aim of this work was to evaluate how primary (P-HIV… CONTINUE READING

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