Primary amebic meningoencephalitis due to Naegleria fowleri: An autopsy case in Japan

@article{Sugita1999PrimaryAM,
  title={Primary amebic meningoencephalitis due to Naegleria fowleri: An autopsy case in Japan},
  author={Yasuo Sugita and Teruhiko Fujii and Itsurou Hayashi and Takachika Aoki and Toshiro Yokoyama and Minoru Morimatsu and Toshihide Fukuma and Yoshiaki Takamiya},
  journal={Pathology International},
  year={1999},
  volume={49}
}
Free‐living amebas represented by Naegleria fowleri, Acanthamoeba and Balamutia have been known to cause fatal meningoencephalitis since Fowler and Carter (1965) reported the first four human cases. An autopsy case of a 25‐year‐old female with primary amebic meningoencephalitis (PAM) due to Naegleria fowleri is described. Headache, lethargy and coma developed in this patient, and her condition progressed to death 8 days after the onset of clinical symptoms. Cerebral spinal fluid examination… 
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References

SHOWING 1-10 OF 12 REFERENCES
Primary amebic meningoencephalitis.
TLDR
An 18-year-old man was admitted to the Tucson Medical Center, Tucson, Ariz, after a two-day history of headache, stiff neck, and fever, where he appeared healthy, alert, and fully oriented, although complaining of headache.
Successful treatment of primary amebic meningoencephalitis.
The fourth documented survivor of primary amebic meningoencephalitis, a young man with a history of waterskiing in a stagnant freshwater lake in northeastern Pennsylvania, is presented. Early…
Laboratory diagnosis of pathogenic free-living amoebas: Naegleria, Acanthamoeba, and Leptomyxid.
Free‐living, Amphizoic and Opportunistic Amebas
Amebas belonging to the genera Naegleria, Acanthamoeba and Balamuthia are free‐living, amphizoic and opportunistic protozoa that are ubiquitous in nature. These amebas are found in soil, water and…
Acute Pyogenic Meningitis Probably Due to Acanthamoeba sp.: a Preliminary Report
A case of granulomatous meningo-encephalitis by Acanthamoeba
  • Niigata Igaku 1987;
  • 1987
An autopsy case of primary amoebic meningoencephalitis due to free living ameba (Leptomyxid)
  • Neuropathology 1991;
  • 1991
An autopsy case of primary amoebic meningoencephalitis
  • Proc . Jpn Soc . Pathol
  • 1996
Primary amebic meningoencephalitis and granulomatous encephalitis due to free-living amebas: Protozoology, epidemiology and neuropathology
  • Neurol. Med. 1980;
  • 1980
An autopsy case of primary amoebic meningoencephalitis
  • Proc. Jpn Soc. Pathol
  • 1996
...
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